James Grogan

B.A., Ph.D.- Professor, Assistant Dean of Curriculum, Department of Biochemistry
Biochemistry

Office: FM01-07
ph: 767-255-6346

Ph.D. - University of California, Santa Barbara

Dr. Grogan began his professional career in 1990 after receiving his PhD from the University of California at Santa Barbara. His research interests concern the biochemistry of proteins and enzymes.

Dr. Grogan began teaching at Ross University in 1995 after a research fellowship at NIH investigating the function of human cytochrome P450 enzymes. He currently teaches biochemistry and genetics in the first and second semester integrated curriculum.

Courses:
Biochemistry/Genetics
PBL

Selected Publications:
Leymarie N, Berg EA, McComb ME, O'Connor PB, Grogan J, Oppenheim, FG, Costello, CE. (2002)
Tandem mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3. Analytical Chemistry 74:4124-32

Grogan J, McKnight CJ, Troxler RF, and Oppenheim FG (2001)
Zinc and copper bind to unique sites of histatin 5 FEBS Letts 491:76-80

Korzekwa KR, Grogan J, DeVito S and Jones JP. (1996)
Electronic models for cytochrome P450 oxidations Adv. Exp. Med. Biol 387:361-369

Grogan J, Shou M, Andrusiak EA, Tamura S, Buters JT, Gonzalez FJ, and Korzekwa KR. (1995)
Cytochrome P450 2A1, 2E1, and 2C9 cDNA-expression by insect cells and partial purification using hydrophobic chromatography. Biochem. Pharmacol. 50:1509-15

Shou M, Grogan J, Mancewicz JA, Krausz KW, Gonzalez FJ, Gelboin HV and Korzekwa KR. (1994)
Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site Biochemistry 33:6450-6455.

Grogan J, Shou M, Zhou D and Korzekwa KR. (1993)
Use of aromatase (CYP450) metabolite ratios to characterize electron transfer from NADPH-Cytochrome P450 reductase. Biochemistry 32:12007-12012

Grogan J, DeVito SC, Pearlman RS and Korzekwa KR. (1992)
Modeling cyanide release from nitriles: Prediction of cytochrome P450 mediated acute nitrile toxicity. Chem. Res. Toxicol . 5:548-552.

Grogan J, Shirazi A and Taborsky G. (1990)
Phosphorus nuclear magnetic resonance of diverse phosvitin species. Comp. Biochem. Physiol 96B: 655-663. 

 

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